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Try out PMC Labs and tell us what you think. To determine the onset and duration of action of sildenafil in patients with erectile dysfunction ED. Two randomised, double-blind, placebo-controlled, two-way crossover studies were conducted in men with ED of no known organic cause. Study II: The duration of grade 3 hard enough for penetration and grade 4 fully hard erections, determined by self-assessment during 60 min of VSS starting 2 and 4 h after sildenafil mg sildenafilo 200mg online placebo dosing, was measured in 16 patients. Study I: The median time range to onset of erections was 27 min in a range of 12—70 after receiving sildenafil 50 mg. When VSS began 4 h postdose, the median duration was 5 min 0—45 for sildenafil compared with 0 min for placebo 0— Sildenafil is an effective oral treatment for ED that produces a penetrative erection as early as 12 min and for most patients, within 30 min after dosing, and a duration of action lasting at least 4 h.
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