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Los agentes de contraste no iónicos más nuevos tienen estructuras mediante las cuales una cadena lateral hidrófila protege el anillo de benceno y esto hace que la molécula sea menos tóxica. Se enumeran las reacciones adversas a los agentes de contraste de yodo, calificadas como leves, moderadas y graves. sin tratamiento; Las reacciones adversas moderadas pueden interferir con el examen radiológico, pero generalmente no requieren tratamiento; y las reacciones adversas graves requieren que el examen sea detenido y tratamiento de emergencia. La fibrosis sistémica nefrogénica se ha relacionado con el uso de agentes de contraste de gadolinio. Esta es una condición en la que hay fibrosis del piel, tejidos conectivos y músculos que causan restricción de la flexión y contracción del extremidades.

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